Gene mutation produces autism-like traits in mice

Wednesday, March 23, 2011

By causing the mutation of one specific gene, researchers have produced mice with two frequently encountered behavioral traits of persons diagnosed with autism. Autism commonly affects the ability to interact socially and is associated with repetitive behavior. The finding was reported in the March 20 online edition of Nature.

Using mice, researchers at the Massachusetts Institute of Technology (MIT) and Duke University mutated one of the genes associated with autism, known as shank3, a gene that controls the production of the shank3 protein present in the brain. Mice that were given this mutation exhibited repetitive behavior and avoided social interactions with the mice around them.

According to MIT Professor Guoping Feng: “Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.”

Shank3 protein are found in synapses within the brain. Synapses allow brain cells (called neurons) to communicate with each other. The mutation in the mouse gene interfered with this communication, apparently producing the subsequent autism-like traits. Researchers believe their work demonstrates the important role of shank3 in the functioning of brain circuits that determine behavior.

While hundreds of genes have been linked to autism in human patients, only a small percentage have been linked to shank3. Professor Feng hypothesizes that disruptions of other genes that act on the production of brain proteins affecting synaptic communication may also be related to autistic behavior. If this disruption is real, Feng claims that treatments could be developed to correct synaptic function for any defective synaptic protein in an autistic patient.

Feng continued; “These findings and the mouse model now allow us to figure out the precise neural circuit defects responsible for these abnormal behaviours, which could lead to novel strategies and targets for developing treatment.”

About one in 110 children in the U.S., and at least one in 100 in UK, have been diagnosed with an autism spectrum disorder, for which there is currently no effective cure.

Retrieved from “https://en.wikinews.org/w/index.php?title=Gene_mutation_produces_autism-like_traits_in_mice&oldid=4050983”

The Foundation Of Medical Training Medical Training Supplies

If you are considering going into the medical industry or ifyou are already involved then you are sure to know the value that medicaltraining supplies hold. Buy purchasing the supplies you enable yourself totrain for real life medical emergencies.Medical training supplies can be anything from a piece of gauze tobigger electronic equipment, such as defibrillators, used by paramedics anddoctors. Spending time on the machines will enable you to become accustomed tothe interface and procedures so that you can confidently use the machine when areal emergency comes up.

What exactly will you need as medical training supplies? Theanswer to this question will differ depending on which medical field you wouldlike to enter. For instance, if you wishto become accredited in first aid then you will need the more basic medicalsupplies. You will need gauze, bandagesand of course a CPR dummy. Learning CPRwill be your biggest challenge, but by using a CPR dummy you will be able toquickly master this skill. Once mastered,you will need to be able to react to different age and physiological aspects ofthe patient or person in need. Forinstance, when doing CPR the force and amount of air you supply will differ ona baby and a full grown adult. With training comes experience and of course thelonger you stick at it the better you will become.

If you plan to become a physiotherapist then you will needto invest in ultrasound and even infra red laser equipment. Learning how to use the equipment is essentialto providing quality care to your patients. In fact if you make a mistake thenyou could be harming the patient instead of helping them. Even professionals need to refresh their trainingand this is often due to the fact new medical equipment is coming out all thetime. If the person doesnt know how tooperate the medical equipment correctly, then accidents and even loss of lifecan occur. Perhaps now it becomes moreevident just how important medical training supplies are. Without these supplies medical training wouldnot be possible or nearly as effective.

Another group of medical personnel who greatly relies on medical training suppliesis paramedics.Paramedics are normally the first on a scene and they need to doeverything in their power to stabilise a persons life. They need to be ableconfidently assess and diagnose a patients injuries and then take propertreatment steps. This will includefastening braces, using defibrillators, setting up IVs and bandagingwounds. All their skills are honedthrough training and by using medical training supplies. In actual fact withoutthese supplies our medical training standards will fall dramatically. Just imaginea medical practitioner arriving on the scene of an accident without ever beenable to practice his techniques and using his equipment. There is no substitute for experience and thishas never been more so than in the medical industry.

Man arrested in connection with Honolulu toddler death

Saturday, January 19, 2008

Matthew Higa, 23, has been arrested in connection with the death of a 23-month-old boy. Higa is alleged to have thrown the child from a pedestrian overpass into oncoming traffic on Honolulu’s H-1 Freeway.

The local coroner’s office noted that the child died on impact after falling 30 feet (9 meters) from the overpass. This occurred during Thursday’s lunch rush hour in the heart of downtown. Upon impact, several cars struck the child, which caused traffic to grind to a halt.

The toddler, Cyrus Nainoa Tupa?i Belt, was pronounced dead at the scene at 12:07 p.m. (2207 UTC), approximately 27 minutes after being allegedly being ejected from the overpass by Higa. The portion of H-1 was closed for approximately five hours with traffic diverted to side streets. The freeway was reopened in time for the evening commute.

At first the relationship between Higa and the child was unclear, but later reports stated that Higa lived adjacent to him and had babysat him on previous occasions. The boy’s mother was out of town at the time of his death, but it was revealed that the child was supposed to be in the custody of his father and not with Higa.

Higa graduated from Roosevelt High School in 2003. In the summer of 2004 Higa was involved in an incident where police reports indicate a three-car race resulted in the death of a friend. Higa has since had a criminal history, with more than a dozen arrests but no convictions, and reports from neighbors of erratic behavior.

Queen’s Medical Center, which houses a psychiatric ward in Honolulu, noted that he was a patient there as recently as December 11, 2007. When arrested, Higa was wearing hospital scrubs, which were not immediately conducive to whether Higa was a patient in Queen’s psychiatric wing in the last couple of days. A representative of Queen’s declined to comment on whether Higa was admitted in the last week.

Retrieved from “https://en.wikinews.org/w/index.php?title=Man_arrested_in_connection_with_Honolulu_toddler_death&oldid=4383349”

Wikinews interviews candidate for Cleveland mayor Arthur Kostendt

Monday, June 14, 2021

Arthur Oliver Kostendt, a candidate running in the mayoral election of the US city of Cleveland, Ohio set to take place November 2, discussed his campaign and policies with Wikinews this spring.

According to Cleveland Scene, 29-year-old Kostendt is a member of the Cuyahoga County, Ohio Republican Party but has referred to his campaign as “casual”. According to his web site’s personal biography, he was a cadet for the Army Reserve Officers’ Training Corps (ROTC), scout platoon leader for the 2nd Squadron of the 107th Cavalry Regiment of the Ohio Army National Guard and logistics officer for the 1st Battalion of the 145th Armored Regiment. He served in Kuwait, Iraq, the United Arab Emirates and Saudi Arabia and assisted coalition force detachments in Southeast Asia.

Kostendt is a graduate of the University of Notre Dame and summa cum laude graduate of Cleveland State University. He writes he uses an apostrophe to abbreviate his middle name as “Arthur O’Kostendt” instead of the customary period after the O to emphasise his Irish heritage.

A poll published May 5 by Baldwin Wallace University, which does not feature Mr Kostendt, has Dennis Kucinich and Basheer Jones leading in the mayoral race by 17.8 and 13.3 points, respectively, with a margin of error of up to five per cent either way. 48% of those surveyed were undecided. Incumbent mayor Frank G. Jackson, who won the 2017 Cleveland mayoral election with 59% of the vote, is eligible for a fifth term but announced on May 6 he would retire.

Retrieved from “https://en.wikinews.org/w/index.php?title=Wikinews_interviews_candidate_for_Cleveland_mayor_Arthur_Kostendt&oldid=4626048”

My New Ceiling Insulation

Submitted by: Lyuben Gergiev

I have considered for a long time to renovate my apartment. Recently that though has become even stronger as I have new neighbors that are very noisy. They have moved in three months ago and the noise they make is unbearable. They have two children that are very young and run around nonstop. They also don t seem to remove their shoes as I can hear the woman s high heels every morning before she goes to work. I have wondered what to do to save myself from all that noise.

The next day I went to visit my sister, which is an architect and lives in the town nearby. I shared my problems with her and to my biggest surprise she had a solution. She told me that her latest project was insulating a building that has just been finished. However, the builders have missed to place insulation and now it has to be done. She said that she found a company called Rockwool that had the best product for that purpose. They have used it and the people living in the building are very happy with the qualities of insulation. I think that is exactly what I need. We had a lunch and a coffee afterwards and then I left.

[youtube]http://www.youtube.com/watch?v=V76ariFeh3Q[/youtube]

The next morning I went on the internet to search some more info for the company and also to get the details of their branches. I was amazed that they had an office in the area I live. I went there straight away to see what they could offer me. I explained the problem to the sales representative and he said that they have the perfect product for me ceiling insulation. The best bit was that the properties of that ceiling insulation were endless however, the ones that concerned me the most were the following fire resistance, water and moisture repellant and soundproofing. What a result! The insulation came in flat pieces and was easy to work with. I used to work as a builder so I was confident that I could do the job properly. I called my mate just to help me. The insulation is lightweight but quite bulky so I needed someone to hand it over to me.

The next day we had it ready and by the end of the day the job was finished. I was very impressed with my new ceiling insulation as it reduced the noise from upstairs and not only that but it is helping to retain the heat in the apartment rather than keeping the neighbors warm.

I would suggest to any of you not to hesitate and purchase this quality insulation from the leader on the market and you will feel the results immediately. The investment is well worth it and will bring you much comfort. Furthermore, you will seal the most common places where the heat escapes from your home during the winter and you will reduce your energy expenses as well.

About the Author: After reading this article I think, you should find prices for ceiling insulation (interesting to know is that the Danish term is

Isolering af loft find priser

) and also

read more

from this article.

Source:

isnare.com

Permanent Link:

isnare.com/?aid=779713&ca=Family+Concerns

UAE to impose corporate tax on business profits

Tuesday, February 1, 2022

On Monday, the United Arab Emirates announced it would impose a federal corporate tax of 9% on business profits, effective from June 1, 2023.

The tax will be levied from all corporations except those involved in “extraction of natural resources”. Businesses with profits up to 375 thousand dirhams will be categorised as small businesses and will be exempted from the tax.

The Emirates has long been a low tax country with no personal tax. The Ministry of Finance said the tax was being imposed to combat tax avoidance and to realign the country on major issues such as the digitalisation of the global economy. It may be linked to a recent international agreement on a minimum global corporate tax rate but the Ministry did not elaborate.

Retrieved from “https://en.wikinews.org/w/index.php?title=UAE_to_impose_corporate_tax_on_business_profits&oldid=4660966”

Wikinews interviews Goronwy Price about the upcoming by-election in the Bradfield electorate of the Australian parliament

Thursday, December 3, 2009

With two federal by-elections coming up in Australia, many minor parties and independents will be looking to gain a seat in the House of Representatives. Goronwy Price is a candidate representing the Environmentalists for Nuclear Energy party.

Mr Price is an environmentalist, adventurer and businessman from the Sydney suburb of Cremorne.

“In 1975 I founded the adventure travel company World Expeditions and built it to be the world’s largest adventure organisation. I am currently Managing Director of Learningportal.com a successful software company I founded in 1997. We export software around the world.,” Mr Price said.

Wikinews reporter Patrick Gillett held an exclusive email interview with Mr Price, candidate for the Division of Bradfield.

Retrieved from “https://en.wikinews.org/w/index.php?title=Wikinews_interviews_Goronwy_Price_about_the_upcoming_by-election_in_the_Bradfield_electorate_of_the_Australian_parliament&oldid=4567771”

US stock markets reach 12-year lows

Thursday, March 5, 2009

US stock markets dropped to twelve-year lows on Thursday, amidst falling confidence in the financial sector and worries over whether the US automobile manufacturer General Motors will be able to keep operating.

The Dow Jones Industrial Average dropped by 4.08%, or 280.52 points, at the closing bell, reaching a level of 6595.32, a new 12-year low. The Nasdaq Composite lost 54.15 points, or 4%, to 1299.59, while the Standard & Poor’s 500 plunged by 30.27 points, or 4.25%, closing at 682.60.

Every stock in the Dow Jones, other than Wal-Mart, either lost ground or remained even, and all stocks in the S&P 500 index lost ground.

General Motors’ shares lost 15.5% after the auto firm announced that its auditors had “substantial doubt” over whether it would be able to keep operating.

Shares of financial companies were lower by nine percent, with Bank of America losing 11.7% and Citigroup falling by 9.7%.

“What’s most worrisome is that we haven’t hit the crescendo yet,” said Bill Groeneveld, the head trader for vFinance Investments. “Asset-management divisions are getting calls to just liquidate everything, and we haven’t seen the big players come back in at all.”

“This is one of the worst bear markets in the last 100 years; it started out with the credit crisis and the subprime [loans], but it is like a forest fire that has raced across the clearing and ignited other parts: Autos, auto parts, the insurance companies have been hit very hard. The credit crisis is causing an unraveling of industry after industry because the banks don’t lend,” said David Dreman, the chief investment officer of Dreman Value Management.

European markets were also lower today, with the London’s FTSE index losing 3.2% and the DAX index of Germany falling by five percent.

Retrieved from “https://en.wikinews.org/w/index.php?title=US_stock_markets_reach_12-year_lows&oldid=783204”

How To Overcome Speech Problem With Invisalign?

Invisalign aligners are now being much preferred by people who desire an awesome smile without making people informed that they are undergoing some dental treatment. Invisalign are spotlessly transparent and hence anybody can rarely detect that you have put them on your teeth. Nevertheless it is a stranger object to your mouth. And therefore in any case when you wear them at the very first moment, you may come across some problem in the way you speak. Here there is a difference regarding the amount of disturbance from person to person. Some particular individuals may find it quite complicated and may go through it for a prolonged period, while certain others may overcome it fast and start talking normally merely within just some days or even hours. Observations during the studies have made it clear that in ninety three percent of Invisalign users, complexity in speech restores to usual swiftly. However when you may face it for the first time you may get worried and may need to resolve it within a short period.

It is not exclusively with Invisalign but with any sort of dental tool that you will experience problem in speaking manner. On the contrary, with Invisalign you will undergo it for less severity, because Invisalign is created from very clear plastic. But, as, it is an unknown substance to your oral cavity, with whatever thickness it gives to your teeth and especially to the spot of hard palate, speech complications are generated essentially, at least to a small degree. A small levelof lisp or spur is observed when you put on your Invisalign on the first occasion, especially when you attempt to pronounce letters like ch, s, j, th, etc since while uttering these sorts of alphabets your tongue comes in contact with your hard palate just on the rear side of the front teeth.

[youtube]http://www.youtube.com/watch?v=P_OGCPfpXLo[/youtube]

The factual worry for Invisalign wearers is for how long they need to experience the speech difficulty. However they must not be frightened, because as claimed by studies it has been proved that around half of the patients get back to their own speech fast.

If you make an effort to get rid of the speech disturbance, you can surely succeed. And for that you must constantly make a practice of speaking. Here some real efforts is needed on your part. You can try tricks for example reading a book audibly or talking consistently to a friend who is familiar with your disturbance. You must practice pronouncing particularly those alphabets which you find tough. Researches have revealed that speech complication can be overcome as fast as only a few hours. For some individuals it can take a few days.

Sometimes it can also happen that you may are under impression that you have complexity in speaking although you may have obtained comfort from it. This is just your excessive consciousness. In this circumstance, just one activity can be of use and it is asking a close person whom you thoroughly trust to confirm whether all your intonations are right. If that person ensures that there is no flaw you should trust it and stop getting tense.

Also one more worry is regarding speaking difficulty at the time of putting on the next set of Invisalign aligners. However as each Invisalign is approximately equal to its precursor the disturbance doesnt take place. Therefore you can notice that speech problem with Invisalign doesnt go on necessarily and if it goes on it remains for a very short period hence you can be undisturbed.

Get It On Film: Benefits Of Hiring A Video Service In Lexington Ky

byadmin

The life of a small business owner is filled with decisions and making the right ones is not always as easy as it seems. Among the most important things a business owner must decide, is how they will market and advertise their business. With all of the various ways out there to get the word about your business out there, none are as effective as a great company video. All of the information you are able to pack into your video will allow you to explain to the watcher what your business does and why they need to choose you. Here is a couple of benefits that come with hiring a Video Service in Lexington KY for your company project.

Getting the Layout RightThe first reason to use a video service for your project is that they can help you get the layout of the video just right. In order for your video to flow correctly, you will need to have a clear idea of where you are going with it and how best to layout. For the most part, a business owner does not have the knowledge needed to get the right layout, which is why using a professional is so beneficial.

Know What to SayAnother reason to use a professional video services is that they will assist you when it comes to the script for your video. They know what it takes to make a video work, which can benefit you greatly when trying to get the right words to say. You need to make sure the script you produce is both filled with information and to the point. The less fluff you have in your video, the better off you will be in the long run. The help you will be able to get from the video service will be invaluable when undertaking this type of project.

At First String Media Productions, you will be able to get the assistance you need to produce a quality video. They are a very Video Service in Lexington KY and can help you out. Call them or go to their website.